Hereditary Breast Cancer Related Genetic Tests
■ Hereditary breast cancer vs. Sporadic breast cancer:
‧Family history: More than one relative on the same side of the family
with the same or related cancer.
‧Inheritance: People with an inherited gene change have a 50% chance to pass down the genetic mutation to children
‧High cancer risk: Mutation carrier has a significantly increased lifetime
risk of developing breast cancer
■ BRCA1 and BRCA2
Breast cancer is the most common cancer found in women. A woman in the general population faces about a 8% lifetime risk of developing
breast cancer. Approximately 3-10% of breast cancer are caused by
hereditary cancer in women with a BRCA1 and BRCA2 mutation.
BRCA1 and BRCA2 genes are tumor suppressor genes. They play a role in ensuring the stability of the cell's genetic material and they have been associated with increased risks of breast cancers. Breast cancers
associated with BRCA1 and BRCA2 mutations tend to develop at
younger ages than their nonhereditary counterparts.
According to the statistics of Europe and United States, in the general
population, the prevalence of BRCA1/BRCA2 mutation is 1 in 200. The lifetime risk of breast cancer in BRCA1 and BRCA2 mutation carriers is
30-50%. A woman with a BRCA1 mutation has a 80% chance of
developing breast cancer and 63% chance of developing ovarian
cancer by age 70. Approximately 80% of women with a BRCA2 mutation will develop breast cancer by age 70, and 5 % will develop breast
cancer by age 70 in men. It is appropriate to offer molecular genetic
testing to determine the risk of breast cancer.
◆ who have cancer in their family
◆ who would like to know the risk of cancer
◆ Associated hereditary cancer : Breast cancer
◆ Genes analyzed : 7 genes
Step1. Consulting with physician to understand the test content
Step2. Go hospitals to collect specimen and fill out the consent form
Step3. Send sepcimen to SOFIVA lab
Step4. DNA extraction and analysis
Step5. The report will be provided in 4 weeks