■ First Trimester Risk Assessment for Early-onset Preeclampsia

During the first trimester, the fetus does not require a large blood supply; therefore, preeclampsia does not affect the health of the baby. However, as the pregnancy progresses, uterine spiral arteries expand to twice their width and provide 16 times as much blood. Arteries that resist expansion cannot provide enough blood to sufficiently supply fetal growth processes, which often leads to fetal growth restriction. In response, the mother’s blood pressure increases in order to provide an adequate amount of blood to the fetus, which results in preeclampsia.

Research has shown that lower levels of placental growth factor (PlGF) and pregnancy-associated plasma protein A (PAPP-A) during the first trimester are highly correlated with the occurrence of early-onset preeclampsia, reduced serum concentrations can lead to poor placental growth. Furthermore, PIGF and PAPP-A are good predictors of preeclampsia, the lower concentrations of both indicate that the earlier preeclampsia occurrence.

■ Risk Assessment for late-onset Preeclampsia

By knowing the sFIt-1/PIGF ratio in the mother’s blood, we can determine the extent of placental insufficiency. If the ratio is less than 38, then placental functions are normal. The risk of preeclampsia is extremely low within next month. Instead, a ratio greater than 38 indicates that placental functions are degraded, which in-turn endangers the normal growth of the fetus. In this case, the mother is advised to undergo treatment according to their doctor’s instructions.

■ Risk Assessment of Preeclampsia in Early Pregnancy

Step1. Consult a physician to obtain a comprehensive understanding of screening.

Step2. The Risk Assessment of Preeclampsia in Early Pregnancy is taken blood samples in 8~13⁺⁶ weeks of gestation. The risk value of Preeclampsia is estimated and analyzed based on the levels of PAPP-A and PIGF in the mother's blood.

Step3. The results will be available in 5 working days.

Step4. The physician explains the report and provides clinical recommendations and precautions.

■ Risk Assessment of Preeclampsia in Late Pregnancy

Step1. Consult a physician to obtain a comprehensive understanding of screening.

Step2. The Risk Assessment of Preeclampsia in Late Pregnancy is taken blood samples in 20~36⁺⁶ weeks of gestation. The risk value of Preeclampsia is estimated and analyzed based on the ratio of sFlt-1 and PIGF in the mother's blood.

Step3. The results will be available in 5 working days.

Step4. The physician explains the report and provides clinical recommendations and precautions.