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NGS-based Preimplantation Genetic Screening (NGS-based PGS)


One sevenths of couples want to have a baby of their own but somehow they just can't. It may due to some possible factors such as infertility, advanced maternal age, repeated miscarriage...and etc.; e

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Introduction


According to the statistics, 1 in 7 couples faces the infertility problems; and there are about a million of In Vitro Fertilization (IVF) cycles carried out worldwide in every year but the pregnancy rate is just 30% to 40%. The main factor of infertility for those women who have recurrent pregnancy loss or repeated implantation failure is chromosomal aneuploidy or structural abnormality, both of which occur to women in advanced age more frequently. By performing Preimplantation Genetic Screening (PGS) to find out the abnormal embryo before implantation, it is able to increase the fertility rate.

American Society for Reproductive Medicine (ASRM), the authority of the European Society of Human Reproduction and artificial reproduction Association Embryology (ESHRE) and the British Fertility Society have indicate that preimplantation screening helps identify chromosomal abnormality; study of ESHRE also points out that it could be 89% chance to find out chromosomal abnormality and substantial increase the success rate of in vitro fertilization (IVF).
(Reference: Human Reproduction, Vol.25, No.4 pp. 821–823, 2010)

Indication


Who is considering proposed IVF and having the following circumstances should simultaneously do NGS-based PGS:

1. Who is advanced maternal age (34 or above).

2. Who has repeated pregnancy loss.

3. Who has repeated implantation failure.

4. Who has a family history of chromosomal abnormalities.

5. Who wants to avoid chromosomal aneuploidies.

Description


SOFIVA GENOMICS has developed preimplantation genetic screening (PGS) for years and had mature technique. Also, we received the affirmation of ISO / IEC 17025 to provide service for many infertile couples.

In 2014, we established Next Generation Sequencing (NGS) platform to replace the traditional array-comparative genomic hybridization (aCGH) to provide a test with higher accuracy and bring hopes to those couples with infertility challenges.

Patient Story


How It Works


Others



In 2014, British teams published the well-known journal of Reproductive Medicine to indicate NGS-based PGS has the following advantages:

◆ The detection rate of chromosomal aneuploidies and unbalanced translocation is 99.9%.
(Reference: Fertil Steril 2014; 101 (5):. 1375-82)

◆ A valuable alternative to the other comprehensive aneuploidy screening techniques since its specificity and sensitivity are both high.
(Reference: Hum Reprod 2014; 29 (12):. 2802-13.)


Now, SOFIVA use the lasted technique "NGS-based PGS" to detect if all 46 chromosomes of the embryos are normal. Physicians could select the appropriate embryos for implantation afterwards in order to reduce the miscarriage or premature delivery caused by chromosomal aneuploidies and improve the pregnancy rate.